Why 3D culture?
While 2D cultures can only mimic physiological tissue conditions to a limited extent, cells can interact in vivo in a three-dimensional network. Therefore, results from 2D cultures can often be limited in clinical efficacy and lead to inaccurate results in the drug development process. For this reason, the use of spheroid cultures helps you to get more reliable results, especially in cancer research, rather than live animal experiments.
In spheroid cultures, cells grow in a three-dimensional system with regions of cellular heterogeneity and nutrient and oxygen gradients to more closely reflect the in-vivo tumor microenvironment. Comparisons of spheroid cultures and 2D cultures show functional differences in tumor cell lines, for example, changes in protein expression, phosphorylation patterns, and responsiveness to inhibitor molecules.
Small pore sizes (0.4 and 1 µm in diameter) for co-culture, diffusion, transporation and secretion studies
Larger pore sizes (3 and 8 µm in diameter) for cell migration and invasion studies
Transparent membranes suitable for light and electron microscopy
Structural and biological 3D modeling with Levitating or Bioprinting methods
Rapid and multiple spheroid formation
Has no effect on cell viability activities
Suitable for all cell lines
Can be used for suspension culture
Easy spheroid formation
You can fill out the form and send it to us to find out in detail which 3D modeling is suitable for you.
